Publikationsdatenbank

Kreuzresistenzen gegenüber antimikrobiellen Wirkstoffen in der Veterinärmedizin:
Molekulare Grundlagen und praktische Bedeutung für die Empfind- lichkeitsprüfung (2005)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Werckenthin, Christiane

Böttner, Alexander

Hafez, H Mohamed

Hartmann, Katrin

Kaske, Martin

Kehrenberg, Corinna

Kietzmann, Manfred

Klarmann, Dieter

Klein, Günter

Krabisch, Peter

Kühn, Tilman

Luhofer, Gabriele

Richter, Angelika

Schulz, Bianka

Schwarz, Stefan

Sigge, Claudia

Traeder, Wolfgang

Waldmann, Karl-Heinz

Wallmann, Jürgen

Quelle

Berliner und Münchener tierärztliche Wochenschrift; 118(11/12) — S. 471–480

ISSN: 0005-9366

Sprache

Englisch

Verweise

Pubmed: 16318271

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Phenotypic resistance of veterinary pathogens to more than one antimicrobial agent (multi-resistance) may be caused by intrinsic resistance to the antimicrobial agents, acquired cross-resistance, or acquired co-resistance. Known cross-resistances allow to select so-called "representative substances" which are tested and the results of which can also be regarded as being valid for other members of the same class of antimicrobial agents. In general, a limitation in the number of antimicrobial agents to be tested in routine diagnostics is necessary because of capacity and cost efficiency. This is of particular relevance when the broth microdilution method - recommended as the method of choice - with 96-well microtiter plates is used. The knowledge about the relationship between different resistance phenotypes and the corresponding resistance mechanisms is of major value for both, the laboratory personnel and the veterinary practitioner. This review explains how "representative substances" for the most relevant classes of antimicrobial agents used in veterinary medicine are chosen on the basis of known cross-resistances.