Publikationsdatenbank

First insights into antimicrobial resistance among faecal Escherichia coli isolates from small wild mammals in rural areas (2010)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Guenther, Sebastian

Grobbel, Mirjam

Heidemanns, Katrin

Schlegel, Mathias

Ulrich, Rainer G

Ewers, Christa

Wieler, Lothar H

Quelle

The science of the total environment : an international journal for scientific research into the environment and its relationship with man

Bandzählung: 408

Heftzählung: 17

Seiten: 3519 – 3522

ISSN: 0048-9697

Sprache

Englisch

Verweise

DOI: 10.1016/j.scitotenv.2010.05.005

Pubmed: 20569968

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Wild rodents can be carriers of antimicrobial resistant Escherichia coli. As rodents are known to be involved in the transmission of bacteria of human and animal health concern, they could likewise contribute to the dissemination of antimicrobial resistant bacteria in the environment. The aim of this study was therefore to get first insights into the antimicrobial resistance status among E. coli isolated from wild small mammals in rural areas. We tested 188 faecal isolates from eight rodent and one shrew species originating from Germany. Preselected resistant isolates were screened by minimal inhibitory concentration (MIC) testing or agar diffusion test and subsequent PCR analysis of resistance genes. The prevalence of antimicrobial resistant isolates was low with only 5.5% of the isolates exhibiting resistant phenotypes against at least one antimicrobial compound including beta-lactams, tetracyclines, aminoglycosides and sulfonamides. These results suggest a minor role of wild rodents from rural areas in the cycle of transmission and spread of antimicrobial resistant E. coli into the environment. Nevertheless E. coli with multiple antimicrobial resistances were significantly more often detected in wildlife rodents originating from areas with high livestock density suggesting a possible transmission from livestock to wild rodents.