Fachbereich Veterinärmedizin


Service-Navigation

    Publikationsdatenbank

    Effect of a dietary n-6 polyunsaturated fatty acid supplement on distinct immune functions of goats. (2004)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Thanasak, J
    Rutten, V. P.
    Schonewille, JT
    Hoek, A
    Beynen, A C
    Noordhuizen, J.
    Müller, K E (WE 20)
    Quelle
    Journal of veterinary medicine a; 51(1) — S. 1–9
    ISSN: 0931-184x
    Sprache
    Englisch
    Verweise
    Pubmed: 15086503
    Kontakt
    Klinik für Klauentiere

    Königsweg 65
    Gebäude 26
    14163 Berlin
    Tel.+49 30 838 62261 Fax.+49 30 838 62512
    email:klauentierklinik@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    The aim of this study was to investigate whether dietary n-6 polyunsaturated fatty acids (PUFA) alter immune functions as lymphocyte blastogenesis, expression of lymphocyte and monocyte markers, and cell adhesion molecules of the integrin family in goats. Dutch White castrated male goats received a diet either rich in olive oil (control group, n = 4) or rich in corn oil (test group, n = 4) over a period of 3 weeks. The animals in the test group had significantly higher linoleic acid (LA, 18:2n-6) levels in plasma on days 7, 14 and 21 of the diet than control animals. This was also true for washed erythrocyte membranes at day 21. A significant reduction in the percentage of alpha-4 integrin (CD49d) expressing lymphocytes was observed in goats fed LA rich corn oil at day 21. However, no changes were observed in either lymphocyte proliferative responses to ConA and PHA or the expression of other lymphocyte/monocyte markers. In conclusion, feeding corn oil rich in LA caused significant increases in the proportion of LA in the fatty acid composition of plasma and erythrocyte membranes and was accompanied by a significant decrease of the adhesion molecule alpha-4 integrin (CD49d) on lymphocytes but not on monocytes.