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    Animal models for drug discovery in dystonia (2008)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Jinnah, Ha
    Richter, Angelika
    Mink, Jonathon W
    Caldwell, Guy A
    Caldwell, Kim A
    Gonzalez-Alegre, Pedro
    Cookson, Mark R
    Breakefield, Xandra O
    Delong, Mahlon R
    Hess, Ellen J
    Quelle
    Expert opinion on drug discovery; 3(1) — S. 83–97
    ISSN: 1746-0441
    Sprache
    Englisch
    Verweise
    DOI: 10.1517/17460441.3.1.83
    Pubmed: 23480141
    Kontakt
    Institut für Pharmakologie und Toxikologie

    Koserstr. 20
    14195 Berlin
    +49 30 838 53221
    pharmakologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Dystonia is a neurological disorder characterized by involuntary twisting movements and unnatural postures. There are many different forms of dystonia, which affect over three million people worldwide. Effective treatments are available only for a minority of patients, so new treatments are sorely needed. Several animal species have been used to develop models for different forms of dystonia, each with differing strengths and weaknesses. This review outlines the strategies that have been used to exploit these models for drug discovery. Some have been used to dissect the pathogenesis of dystonia for the identification of molecular targets for intervention. Others have been used for the empirical identification of candidate drugs. Therefore, the animal models provide promising new tools for developing better treatments for dystonia.