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    A proposal of clinical breakpoints for amoxicillin applicable to porcine respiratory tract pathogens (2008)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Schwarz, Stefan
    Böttner, Alexander
    Goossens, Luc
    Goosens, Luc
    Hafez, H Mohamed
    Hartmann, Katrin
    Kaske, Martin
    Kehrenberg, Corinna
    Kietzmann, Manfred
    Klarmann, Dieter
    Klein, Günter
    Krabisch, Peter
    Luhofer, Gabriele
    Richter, Angelika
    Schulz, Bianka
    Sigge, Claudia
    Waldmann, Karl-Heinz
    Wallmann, Jürgen
    Werckenthin, Christiane
    Quelle
    Veterinary Microbiology; 126(1/3) — S. 178–188
    ISSN: 0378-1135
    Sprache
    Englisch
    Verweise
    Pubmed: 17686589
    Kontakt
    Institut für Pharmakologie und Toxikologie

    Koserstr. 20
    14195 Berlin
    Tel.+49 30 838 53221 Fax.+49 30 838 53112
    email:pharmakologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    In the present position paper, an attempt was made to establish clinical breakpoints of amoxicillin to classify porcine respiratory tract pathogens as susceptible, intermediate or resistant based on their minimum inhibitory concentrations of amoxicillin. For this, a thorough review of the published literature with regard to swine-specific pharmacological data (including dosages of amoxicillin applied and routes of administration used), clinical efficacy, and in vitro susceptibility of the target pathogens was performed. Based on the comparative analysis of the results, the working group "Antibiotic Resistance" of the German Veterinary Medical Society (DVG) proposed to classify porcine respiratory tract pathogens that show MIC values of amoxicillin of < or =0.5microg/ml as "susceptible", those with MICs of 1microg/ml as "intermediate", and those with MICs of > or =2microg/ml as "resistant".