Fachbereich Veterinärmedizin



    High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster (2009)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Reese, René
    Charron, Giselle
    Nadjar, Agnès
    Aubert, Incarnation
    Thiolat, Marie-Laure
    Hamann, Melanie
    Richter, Angelika
    Bezard, Erwan
    Meissner, Wassilios G
    Neurobiology of Disease; 35(3) — S. 399–405
    ISSN: 0969-9961
    DOI: 10.1016/j.nbd.2009.05.022
    Pubmed: 19501651
    Institut für Pharmakologie und Toxikologie

    Koserstr. 20
    14195 Berlin
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    Abstract / Zusammenfassung

    High frequency stimulation (HFS) of the internal pallidum is effective for the treatment of dystonia. Only few studies have investigated the effects of stimulation on the activity of the cortex-basal ganglia network. We here assess within this network the effect of entopeduncular nucleus (EP) HFS on the expression of c-Fos and cytochrome oxidase subunit I (COI) in the dt(sz)-hamster, a well-characterized model of paroxysmal dystonia. In dt(sz)-hamsters, we identified abnormal activity in motor cortex, basal ganglia and thalamus. These structures have already been linked to the pathophysiology of human dystonia. EP-HFS (i) increased striatal c-Fos expression in controls and dystonic hamsters and (ii) reduced thalamic c-Fos expression in dt(sz)-hamsters. EP-HFS had no effect on COI expression. The present results suggest that EP-HFS induces a new network activity state which may improve information processing and finally reduces the severity of dystonic attacks in dt(sz)-hamsters.