Publikationsdatenbank

High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster (2009)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Reese, René

Charron, Giselle

Nadjar, Agnès

Aubert, Incarnation

Thiolat, Marie-Laure

Hamann, Melanie

Richter, Angelika

Bezard, Erwan

Meissner, Wassilios G

Quelle

Neurobiology of Disease

Bandzählung: 35

Heftzählung: 3

Seiten: 399 – 405

ISSN: 0969-9961

Sprache

Englisch

Verweise

DOI: 10.1016/j.nbd.2009.05.022

Pubmed: 19501651

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

High frequency stimulation (HFS) of the internal pallidum is effective for the treatment of dystonia. Only few studies have investigated the effects of stimulation on the activity of the cortex-basal ganglia network. We here assess within this network the effect of entopeduncular nucleus (EP) HFS on the expression of c-Fos and cytochrome oxidase subunit I (COI) in the dt(sz)-hamster, a well-characterized model of paroxysmal dystonia. In dt(sz)-hamsters, we identified abnormal activity in motor cortex, basal ganglia and thalamus. These structures have already been linked to the pathophysiology of human dystonia. EP-HFS (i) increased striatal c-Fos expression in controls and dystonic hamsters and (ii) reduced thalamic c-Fos expression in dt(sz)-hamsters. EP-HFS had no effect on COI expression. The present results suggest that EP-HFS induces a new network activity state which may improve information processing and finally reduces the severity of dystonic attacks in dt(sz)-hamsters.