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    Deletion of the Ferric Uptake Regulator Fur Impairs the in vitro Growth and Virulence of Actinobacillus Pleuropneumoniae (2005)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Jacobsen, Ilse
    Gerstenberger, Jörg
    Gruber, Achim D
    Bossé, Janine T
    Langford, Paul R
    Hennig-Pauka, Isabel
    Meens, Jochen
    Gerlach, Gerald-F
    Quelle
    Infection and immunity; 73(6) — S. 3740–3744
    ISSN: 0019-9567
    Sprache
    Englisch
    Verweise
    Pubmed: 15908404
    Kontakt
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    Tel.+49 30 838 62450 Fax.+49 30 838 62522

    Abstract / Zusammenfassung

    In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Deltafur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.