Publikationsdatenbank

Deletion of the Ferric Uptake Regulator Fur Impairs the in vitro Growth and Virulence of Actinobacillus Pleuropneumoniae (2005)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Jacobsen, Ilse

Gerstenberger, Jörg

Gruber, Achim D

Bossé, Janine T

Langford, Paul R

Hennig-Pauka, Isabel

Meens, Jochen

Gerlach, Gerald-F

Quelle

Infection and immunity

Bandzählung: 73

Heftzählung: 6

Seiten: 3740 – 3744

ISSN: 0019-9567

Sprache

Englisch

Verweise

Pubmed: 15908404

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Deltafur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.