Publikationsdatenbank

Chronic Antigen Stimulation in vivo Induces a Distinct Population of Antigen-specific Foxp3 CD25 Regulatory T Cells (2007)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Hansen, Wiebke

Westendorf, Astrid M

Reinwald, Simone

Bruder, Dunja

Deppenmeier, Stefanie

Groebe, Lothar

Probst-Kepper, Michael

Gruber, Achim D

Geffers, Robert

Buer, Jan

Quelle

Journal of immunology

Bandzählung: 179

Heftzählung: 12

Seiten: 8059 – 8068

ISSN: 0022-1767

Sprache

Englisch

Verweise

Pubmed: 18056346

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The concept of immune regulation/suppression has been well-established and, besides thymus-derived CD4+CD25+ regulatory T (TR) cells, it became clear that a variety of additional peripherally induced TR cells play vital roles in protection from many harmful immune responses including intestinal inflammation. In the present study, we have analyzed in vivo-induced Ag-specific CD4+ TR cells with respect to their molecular and functional phenotype. By comparative genomics we could show that these Ag-specific TR cells induced by chronic Ag stimulation in vivo clearly differ in their genetic program from naturally occurring thymus-derived CD4+CD25+ TR cells. This distinct population of induced TR cells express neither CD25 nor the TR-associated transcription factor Foxp3. Strikingly, CD25 is not even up-regulated upon stimulation. Despite the lack in Foxp3 expression, these in vivo-induced CD25- TR cells are able to interfere with an Ag-specific CD8+ T cell-mediated intestinal inflammation without significant increase in CD25 and Foxp3 expression. Thus, our results demonstrate that in vivo-induced Ag-specific TR cells represent a distinct population of Foxp3-CD25- TR cells with regulatory capacity both in vitro and in vivo.