Fachbereich Veterinärmedizin



    Chronic Antigen Stimulation in vivo Induces a Distinct Population of Antigen-specific Foxp3 CD25 Regulatory T Cells (2007)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Hansen, Wiebke
    Westendorf, Astrid M
    Reinwald, Simone
    Bruder, Dunja
    Deppenmeier, Stefanie
    Groebe, Lothar
    Probst-Kepper, Michael
    Gruber, Achim D
    Geffers, Robert
    Buer, Jan
    Journal of immunology; 179(12) — S. 8059–8068
    ISSN: 0022-1767
    Pubmed: 18056346
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    +49 30 838 62450

    Abstract / Zusammenfassung

    The concept of immune regulation/suppression has been well-established and, besides thymus-derived CD4+CD25+ regulatory T (TR) cells, it became clear that a variety of additional peripherally induced TR cells play vital roles in protection from many harmful immune responses including intestinal inflammation. In the present study, we have analyzed in vivo-induced Ag-specific CD4+ TR cells with respect to their molecular and functional phenotype. By comparative genomics we could show that these Ag-specific TR cells induced by chronic Ag stimulation in vivo clearly differ in their genetic program from naturally occurring thymus-derived CD4+CD25+ TR cells. This distinct population of induced TR cells express neither CD25 nor the TR-associated transcription factor Foxp3. Strikingly, CD25 is not even up-regulated upon stimulation. Despite the lack in Foxp3 expression, these in vivo-induced CD25- TR cells are able to interfere with an Ag-specific CD8+ T cell-mediated intestinal inflammation without significant increase in CD25 and Foxp3 expression. Thus, our results demonstrate that in vivo-induced Ag-specific TR cells represent a distinct population of Foxp3-CD25- TR cells with regulatory capacity both in vitro and in vivo.