Publikationsdatenbank

IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury (2008)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Braun, Ruedi K

Ferrick, Christina

Neubauer, Paul

Sjoding, Michael

Sterner-Kock, Anja

Kock, Martin

Putney, Lei

Ferrick, David A

Hyde, Dallas M

Love, Robert B

Quelle

Inflammation

Bandzählung: 31

Heftzählung: 3

Seiten: 167 – 179

ISSN: 0360-3997

Sprache

Englisch

Verweise

DOI: 10.1007/s10753-008-9062-6

Pubmed: 18338242

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

gammadelta T cells play a key role in the regulation of inflammatory responses in epithelial tissue, and in adaptive immunity, as gammadelta T cell deficient mice have a severely impaired capacity to clear lung pathogens. gammadelta T cells regulate the initial inflammatory response to microbial invasion and thereby protect against tissue injury. Here we examined the response of gammadelta T cells to lung injury induced by bleomycin, in an effort to study the inflammatory response in the absence of any adaptive immune response to a pathogen.

After lung injury by bleomycin, we localized the gammadelta T cells to the lung lesions. gammadelta T cells were the predominant source of IL-17 (as detected by flow cytometry and real-time PCR). Moreover, gammadelta T cell knockout mice showed a significant reduction in cellular infiltration into the airways, reduced expression of IL-6 in the lung, and a significant delay in epithelial repair.

Mouse gammadelta T cells produce IL-17 in response to lung injury and are required for an organized inflammatory response and epithelial repair. The lack of gammadelta T cells correlates with increased inflammation and fibrosis.