Fachbereich Veterinärmedizin



    IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury (2008)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Braun, Ruedi K
    Ferrick, Christina
    Neubauer, Paul
    Sjoding, Michael
    Sterner-Kock, Anja
    Kock, Martin
    Putney, Lei
    Ferrick, David A
    Hyde, Dallas M
    Love, Robert B
    Inflammation; 31(3) — S. 167–179
    ISSN: 0360-3997
    DOI: 10.1007/s10753-008-9062-6
    Pubmed: 18338242
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    +49 30 838 62450

    Abstract / Zusammenfassung

    gammadelta T cells play a key role in the regulation of inflammatory responses in epithelial tissue, and in adaptive immunity, as gammadelta T cell deficient mice have a severely impaired capacity to clear lung pathogens. gammadelta T cells regulate the initial inflammatory response to microbial invasion and thereby protect against tissue injury. Here we examined the response of gammadelta T cells to lung injury induced by bleomycin, in an effort to study the inflammatory response in the absence of any adaptive immune response to a pathogen.

    After lung injury by bleomycin, we localized the gammadelta T cells to the lung lesions. gammadelta T cells were the predominant source of IL-17 (as detected by flow cytometry and real-time PCR). Moreover, gammadelta T cell knockout mice showed a significant reduction in cellular infiltration into the airways, reduced expression of IL-6 in the lung, and a significant delay in epithelial repair.

    Mouse gammadelta T cells produce IL-17 in response to lung injury and are required for an organized inflammatory response and epithelial repair. The lack of gammadelta T cells correlates with increased inflammation and fibrosis.