Fachbereich Veterinärmedizin



    Prevalence of Feline Leukaemia Provirus DNA in Feline Lymphomas (2010)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Weiss, Alexander Th A
    Klopfleisch, Robert
    Gruber, Achim D
    Journal of feline medicine and surgery; 12(12) — S. 929–935
    ISSN: 1098-612x
    DOI: 10.1016/j.jfms.2010.07.006
    Pubmed: 21036089
    Institut für Tierpathologie

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    Abstract / Zusammenfassung

    A significant drop in the prevalence of feline leukaemia virus (FeLV) antigenaemic cats and antigen-associated lymphomas has been observed after the introduction of FeLV vaccination and antigen-testing with removal of persistently antigenaemic cats. However, recent reports have indicated that regressively infected cats may contain FeLV provirus DNA and that lymphoma development may be associated with the presence of provirus alone. In the present study, we investigated the presence of FeLV antigen and provirus DNA in 50 lymphomas by immunohistochemistry and semi-nested polymerase chain reaction, respectively. Interestingly, almost 80% of T-cell lymphomas and 60% of B-cell lymphomas contained provirus DNA while only 21% of T-cell lymphomas and 11% of B-cell lymphomas expressed FeLV antigen. In conclusion, our results support previous hypotheses that vaccination and removal of persistently antigenaemic cats have led to a drop in FeLV antigen-expressing lymphomas. However, FeLV provirus DNA is still present in a high percentage of feline lymphomas.