Publikationsdatenbank

Prevalence of Feline Leukaemia Provirus DNA in Feline Lymphomas (2010)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Weiss, Alexander Th A

Klopfleisch, Robert

Gruber, Achim D

Quelle

Journal of feline medicine and surgery : official journal of the European Society of Feline Medicine

Bandzählung: 12

Heftzählung: 12

Seiten: 929 – 935

ISSN: 1098-612x

Sprache

Englisch

Verweise

DOI: 10.1016/j.jfms.2010.07.006

Pubmed: 21036089

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

A significant drop in the prevalence of feline leukaemia virus (FeLV) antigenaemic cats and antigen-associated lymphomas has been observed after the introduction of FeLV vaccination and antigen-testing with removal of persistently antigenaemic cats. However, recent reports have indicated that regressively infected cats may contain FeLV provirus DNA and that lymphoma development may be associated with the presence of provirus alone. In the present study, we investigated the presence of FeLV antigen and provirus DNA in 50 lymphomas by immunohistochemistry and semi-nested polymerase chain reaction, respectively. Interestingly, almost 80% of T-cell lymphomas and 60% of B-cell lymphomas contained provirus DNA while only 21% of T-cell lymphomas and 11% of B-cell lymphomas expressed FeLV antigen. In conclusion, our results support previous hypotheses that vaccination and removal of persistently antigenaemic cats have led to a drop in FeLV antigen-expressing lymphomas. However, FeLV provirus DNA is still present in a high percentage of feline lymphomas.