Publikationsdatenbank

A proposal of clinical breakpoints for amoxicillin applicable to porcine respiratory tract pathogens. (2008)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Schwarz, S.

Böttner, A.

Goosens, L.

Hafez, H. M.

Hartmann, K.

Kaske, M.

Kehrenberg, C.

Kietzmann, M.

Klarmann, D.

Klein, G.

Krabisch, P.

Luhofer, G.

Richter, A.

Schulz, B.

Sigge, C.

Waldmann, K. H.

Wallmann, J.

Werckenthin, C.

Quelle

Veterinary microbiology : an international journal

Bandzählung: 126

Heftzählung: 1-3

Seiten: 178 – 188

ISSN: 0378-1135

Sprache

Englisch

Verweise

Pubmed: 17686589

Kontakt

Nutztierklinik: Abteilung Geflügel

Königsweg 63
14163 Berlin
+49 30 838 62676
gefluegelkrankheiten@vetmed.fu-berlin.de

Abstract / Zusammenfassung

In the present position paper, an attempt was made to establish clinical breakpoints of amoxicillin to classify porcine respiratory tract pathogens as susceptible, intermediate or resistant based on their minimum inhibitory concentrations of amoxicillin. For this, a thorough review of the published literature with regard to swine-specific pharmacological data (including dosages of amoxicillin applied and routes of administration used), clinical efficacy, and in vitro susceptibility of the target pathogens was performed. Based on the comparative analysis of the results, the working group "Antibiotic Resistance" of the German Veterinary Medical Society (DVG) proposed to classify porcine respiratory tract pathogens that show MIC values of amoxicillin of < or =0.5microg/ml as "susceptible", those with MICs of 1microg/ml as "intermediate", and those with MICs of > or =2microg/ml as "resistant".