Fachbereich Veterinärmedizin



    Chronic heart failure due to severe endocardiosis in a Gambian giant pouched rat (Cricetomys gambianus) (2010)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Müller, Kerstin
    Horn, Britta
    Fritsch, Guido
    Range, Friederike
    Klopfleisch, Robert
    Journal of zoo and wildlife medicine : official publ. of the American Association of Zoo Veterinarians; 41(1) — S. 137–139
    ISSN: 1042-7260
    Pubmed: 20722267
    Institut für Tierpathologie

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    Abstract / Zusammenfassung

    A 1.5-yr-old captive male Gambian giant pouched rat (Cricetomys gambianus) died after suffering from anorexia, weakness, and dyspnea for 3 wk. Thoracic radiographs of thorax and abdomen and computed tomography showed a severe biventricular enlargement of the heart and a moderate hepatomegaly. Necropsy revealed a severe, bilateral hypertrophic cardiomyopathy and dilation of the right ventricle due to multifocal bilateral, valvular endocardiosis of all atrioventricular valves and acute hepatic congestion. Histologically, the atrioventricular valves were multifocally thickened by a marked endocardiosis with stromal accumulation of Periodic acid-Schiff (PAS)-positive, mucinous material. Although common in dogs, endocardiosis has not been described in Nesomyidaes. As in other affected species, the pathogenesis of endocardiosis in this species remains unclear.