Fachbereich Veterinärmedizin



    Five Cases of Pigmented Paravenous Retinochoroidal Atrophy in Dogs (2012)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Linek, Jens
    Gruber, Achim D
    Mecklenburg, Lars
    Veterinary Ophthalmology; 15(Suppl 2) — S. 41–47
    ISSN: 1463-5216
    DOI: 10.1111/j.1463-5224.2012.01006.x
    Pubmed: 22432693
    Institut für Tierpathologie

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    Gebäude 12
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    Abstract / Zusammenfassung

    To describe a funduscopic finding in dogs that is referred to as Pigmented Paravenous Retinochoroidal Atrophy (PPRCA).

    Over a period of 24 years of ophthalmological practice, five cases of a characteristic paravenous retinal atrophy were observed in dogs.

    A comprehensive clinical ophthalmological examination in all five dogs was complemented by abdominal sonography (cases 1, 3), clinical pathology analysis (cases 1, 3, 4), and a histological examination of both bulbi, kidneys, spleen, and liver in one dog (case 1).

    Localized hyper-reflectivity in the tapetal fundus was observed in all five dogs and demonstrated a characteristic perivascular distribution along some peripheral retinal blood vessels. In these areas, geographic copper-brown coloration that tended to become darker with time was seen. Ophthalmoscopic signs of inflammation were lacking. The funduscopic abnormalities slowly progressed in size over years. Visual impairment could not be detected. Histopathology in one dog revealed severe retinal atrophy with multifocal perivascular distribution, mainly affecting the tapetal fundus and occasionally expanding into the nontapetal fundus.

    The described retinal lesions bear similarities with PPRCA in humans. As in humans, it appears to be an incidental funduscopic finding that is not associated with obvious vision impairment.