Publikationsdatenbank

Detection and isolation of equine herpesviruses 1 and 4 from horses in Normandy:
an autopsy study of tissue distribution in relation to vaccination status (2002)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Taouji, S

Collobert, C

Gicquel, B

Sailleau, C

Brisseau, N

Moussu, C

Breuil, M F

Pronost, S

Borchers, K

Zientara, S

Quelle

Journal of veterinary medicine = Zentralblatt für Veterinärmedizin : Series B, Infectious diseases, immunobiology, food hygiene, public health

Bandzählung: 49

Heftzählung: 8

Seiten: 394 – 399

ISSN: 0721-1856

Sprache

Englisch

Verweise

Pubmed: 12449249

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Equine herpesviruses type 1 and 4 (EHV-1 and EHV-4) are ubiquitous in the equine population. One of their main properties is their ability to establish life-long latent infections in their hosts even in those with natural or vaccine-induced immunity. However, effect of vaccination status on prevalence and tissue tropism was not established. In this study, EHV-1 and EHV-4 were detected by polymerase chain reaction and by classical virus isolation from neural, epithelial and lymphoid tissues collected from unvaccinated (33) or vaccinated (23) horses. The percentage of EHV-1- and EHV-4-positive horses between vaccinates and unvaccinates was similar. Both viruses were detected in all tissues of both groups; in particular, lymph nodes draining the respiratory tract, nasal epithelium and nervous ganglia [i.e. trigeminal ganglia (TG)], which represent the main positive sites for EHV-1 and EHV-4. In vaccinated animals, the nervous ganglia (i.e. TG) were less frequently positive than in unvaccinated animals. Detection of positive TG was strongly correlated to the presence of EHV-1 in nasal epithelium.