Publikationsdatenbank

The mouse is not permissive for equine herpesvirus 2 (EHV-2), however viral DNA persisted in lung and spleen depending on the inoculation route (2002)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Borchers, K

Brackmann, J

Kershaw, O

Quelle

Archives of virology : official journal of the Virology Division of the International Union of Microbiological Societies

Bandzählung: 147

Heftzählung: 7

Seiten: 1437 – 1444

ISSN: 0304-8608

Sprache

Englisch

Verweise

Pubmed: 12111417

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

BALB/c mice were inoculated with 3 EHV-2 low passage isolates. After intranasal inoculation, viral DNA was detected by virus-specific nested PCR in the lung up to day 30 post inoculation and in nasal turbinates till day 7. In trigeminal ganglia, olfactory bulb, brain and lymph nodes viral DNA was randomly shown by PCR. After intraperitoneal inoculation viral DNA was present in lymphoid tissues. The spleen was PCR positive up to day 30 and showed a splenomegaly. Clinical signs, virus replication and viraemia, were not observed and no virus strain-specific differences were obvious. Control mice inoculated with equine herpesvirus 4 were PCR negative in all tissues.