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    Characterization of equid herpesvirus 1 (EHV-1) related viruses from captive Grevy's zebra and blackbuck (2006)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Borchers, Kerstin
    Böttner, Daniel
    Lieckfeldt, Dietmar
    Ludwig, Arne
    Frölich, Kai
    Klingeborn, Berndt
    Widèn, Frederik
    Allen, George
    Ludwig, Hanns
    Quelle
    The Journal of veterinary medical science / the Japanese Society of Veterinary Science; 68(7) — S. 757–760
    ISSN: 0916-7250
    Sprache
    Englisch
    Verweise
    Pubmed: 16891794
    Kontakt
    Institut für Virologie

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14163 Berlin
    +49 30 838 51833
    viro@zedat.fu-berlin.de

    Abstract / Zusammenfassung

    Equid herpes virus 1 (EHV-1) related isolates from a captive blackbuck (strain Ro-1) and Grevy's zebra (strain T965) behaved similarly to EHV-1 and EHV-9 in respect to their host cell range. Restriction enzyme analysis and a phylogenetic tree confirmed that Ro-1 and T965 were identical and more closely related to EHV-1 than to EHV-9. Differences from EHV-1 became obvious firstly, by amino acid alignments revealing two unique substitutions in the gB protein of Ro-1 and T965. Secondly, an EHV-1 type-specific monoclonal antibody did not detect its antigen on Ro-1, T965 or EHV-9 infected cells by immunohistochemistry. The results support the view that Ro-1 and T965 isolates represent a distinct, previously unrecognized species of equid herpesviruses.