Publikationsdatenbank

Characterization of equid herpesvirus 1 (EHV-1) related viruses from captive Grevy's zebra and blackbuck (2006)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Borchers, Kerstin

Böttner, Daniel

Lieckfeldt, Dietmar

Ludwig, Arne

Frölich, Kai

Klingeborn, Berndt

Widèn, Frederik

Allen, George

Ludwig, Hanns

Quelle

The Journal of veterinary medical science / the Japanese Society of Veterinary Science

Bandzählung: 68

Heftzählung: 7

Seiten: 757 – 760

ISSN: 0916-7250

Sprache

Englisch

Verweise

Pubmed: 16891794

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Equid herpes virus 1 (EHV-1) related isolates from a captive blackbuck (strain Ro-1) and Grevy's zebra (strain T965) behaved similarly to EHV-1 and EHV-9 in respect to their host cell range. Restriction enzyme analysis and a phylogenetic tree confirmed that Ro-1 and T965 were identical and more closely related to EHV-1 than to EHV-9. Differences from EHV-1 became obvious firstly, by amino acid alignments revealing two unique substitutions in the gB protein of Ro-1 and T965. Secondly, an EHV-1 type-specific monoclonal antibody did not detect its antigen on Ro-1, T965 or EHV-9 infected cells by immunohistochemistry. The results support the view that Ro-1 and T965 isolates represent a distinct, previously unrecognized species of equid herpesviruses.