Publikationsdatenbank

Phenyl phosphorodiamidate (PPD) adversely affects the electrophysiology of the rumen epithelium in sheep (2007)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Abdoun, K.

Martens, H.

Quelle

Online Journal of Veterinary Research

Bandzählung: 11

Heftzählung: 22

Seiten: 38 – 44

ISSN: 1328-925x

Sprache

Englisch

Verweise

URL (Volltext): http://www.comcen.com.au/%7Ejournals/rumensheepabs2007.htm

Kontakt

Institut für Veterinär-Physiologie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62600
physiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The effect of mucosal application of 1mmol/l phenyl phosphorodiamidate (PPD) on the electrophysiology of isolated rumen epithelium was studied in vitro using a conventional Ussing chamber technique. Thirty-six isolated rumen epithelium samples from 5 sheep of different breeds, age and sex and solely fed on hay were used. Mucosal application of phenyl phosphorodiamidate, which has an application in improving the utilization of dietary urea in ruminants nutrition, on the mucosal side of ruminal epithelial tissues resulted in a significant (p<0.05) reduction of the transepithelial potential difference (PDt) and epithelial short circuit current (Isc), and a significant (p<0.05) elevation of the epithelial tissue conductance (Gt). Phenyl phosphorodiamidate could thus impair the barrier and transport function of the rumen epithelium.