Publikationsdatenbank

Prolonged application of clopidogrel reduces inflammation after percutaneous coronary intervention in the porcine model (2007)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Ayral, Y.

Rauch, U.

Goldin-Lang, P.

Stellbaum, C.

Deiner, C.

Schwimmbeck, P. L.

Schultheiss, H. P.

Pels, K.

Quelle

Cardiovascular revascularization medicine

Bandzählung: 8

Heftzählung: 3

Seiten: 183 – 188

ISSN: 1553-8389

Sprache

Englisch

Verweise

DOI: 10.1016/j.carrev.2007.03.003

Pubmed: 17765648

Kontakt

Institut für Veterinär-Physiologie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62600
physiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

OBJECTIVE:
We determined the effect of prolonged treatment with clopidogrel on C-reactive protein (CRP) concentrations and blood thrombogenicity after percutaneous transluminal coronary angioplasty followed by intracoronary brachytherapy in the porcine model. ANIMAL MODEL: All 48 pigs received antiplatelet therapy, including aspirin (325 mg, daily) and clopidogrel (300 mg, loading dose) 1 day before PCI, followed by a daily dose of clopidogrel (75 mg/day) in addition to aspirin. During PCI, one of two balloon-injured arteries was randomly assigned to receive immediate radiation treatment. Animals were sacrificed after 24 h, 1 month, and 3 months post-PCI. The pigs, which were sacrificed 3 months post-PCI, were divided into two groups. The first group received clopidogrel in addition to aspirin for 3 months, and the second group received clopidogrel in addition to aspirin for only 1 month after PCI and then aspirin alone.

METHODS:
Blood was taken from all pigs before intervention, immediately after intervention, and before sacrifice. Serum CRP was measured by enzyme-linked immunosorbent assay. To analyze the procoagulant effects of PCI on blood thrombogenicity, a one-stage clotting assay was performed.

RESULTS:
Clopidogrel treatment for 3 months reduced CRP levels more than did clopidogrel therapy for 1 month only at 3 months post-PCI (27.9+/-3.9 vs. 56.6+/-11.3 mug/ml; P=.019). Baseline CRP levels were found to be 50.4+/-4.8 mug/ml. Plasma clotting was not affected by prolonged clopidogrel therapy (322.8+/-59.3 s vs. 295.2+/-52.5 s; P=ns).

CONCLUSIONS: Prolonged treatment with clopidogrel reduced CRP levels post-PCI.