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    Idiopathische immunbedingte Polyarthritis Typ I beim Hund:
    Inzidenz, Klinik, Laborbefunde, Therapie und Verlauf von 16 Fällen (1996-2000) (2005)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Kohn, B.
    Lübke, S.
    Schmidt, M. F. G.
    Brunnberg, L.
    Quelle
    Kleintier-Praxis; 50(7) — S. 415–426
    ISSN: 0023-2076
    Kontakt
    Institut für Immunologie und Molekularbiologie

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14163 Berlin
    Tel.+49 30 838 - 518 34 Fax.+49 30 838 451 834

    Abstract / Zusammenfassung

    In a retrospective study, 35 dogs with immune-mediated polyarthritis (IPA) presented to the Clinic for Small Animals, Free University of Berlin, over a time period of 4 years, were grouped into the different IPA forms based on clinical, radiological and laboratory results. Three dogs suffered from erosive rheumatoid arthritis. The remaining dogs had a non-erosive form of IPA: idiopathic IPA type I (without underlying disease, n=16), IPA type II (reactive arthritis, 4), IPA type III (enteropathic arthritis, 2), IPA type IV (associated with neoplasia, 1), Systemic lupus erythematosus (3), vaccination-associated (5), polyarthritis/meningitis-syndrome (1). Sixteen dogs were diagnosed with idiopathic IPA type I. Four of the 16 dogs were mixed-breeds. The other dogs belonged to 10 different breeds. There was an equal gender distribution. Their ages ranged from 1.5-12 years (median 4.5). Nine dogs were presented due to acute and 7 due to chronic locomotion disorders (difficulty in getting up, stiff gait, changing lamenesses). In all dogs one or more joints were painful. In most of them swellings of the joints were palpable. Ten dogs were febrile and 7 inappetent. Radiographs revealed soft tissue swelling and/or joint effusion of affected joints. In seven dogs the spleen was enlarged. Synovial fluid analysis of several joints revealed an increased number of nucleated cells (1.100-87,000/ micro l, median 16,200) and an increased amount of neutrophils (19-98%, median 80). Other abnormalities of laboratory results were non-specific and included leukocytosis (n=19 dogs), mild non-regenerative anemia (4), thrombocytopenia (3), hyperglobulinemia (3). Two of the 16 dogs did not show any clinical signs after treatment with antibiotics and NSAIDs. The other 14 dogs received immunosuppressive dosages of prednisolone, either alone (5) or combined with cytotoxic drugs (9). All dogs initially responded to their therapy. However, 7 dogs (44%) relapsed either while receiving drugs (5) or after withdrawal (2). Lethality rate was 12.5% (n=2), both of these dogs were euthanized due to progression of their disease after