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    GK 1121- Functional analysis of immunomodulating proteins of parasitic nematodes

    Projektbeschreibung:

    A panel of four recombinantly produced immunodominant proteins of filarial nematodes (tropomyosin, chitinase, 33kD protein and cystatin) are studied. These proteins predominantly induce IgG1 production in mouse and IgG4 in humans. All these proteins have been cloned and expressed from the human pathogenic filariae Onchocerca volvulus and the rodent filariae Acanthocheilonema viteae. Within the project we comparatively study the role of antibody subclasses generated against these proteins, and of ICs in sera of rodents and humans after nematode infection or immunizations.

    Projektleitung: Univ.-Prof. Dr. Susanne Hartmann
    Eintragende Einrichtung: Institut für Immunologie und Molekularbiologie
    Projektlaufzeit: 01.10.2009 bis 31.03.2014
    Projekttyp: Forschungsprojekt
    Mittelgeber: DFG