Fachbereich Veterinärmedizin



    SPP 1313 Biologicals Responses to Nanoscale Particles (Bio-Nano-Responses): Nanopartikels Containing Selective Probes: Interaction Mechanisms of Nanoparticles with Cell Membranes, Intracellular Uptake, and Transport (NANO-SELECT)


    The goals of the project are (i) acute and chronic local, regional and systematic tracing of functionalized particles following topical application to the skin, (ii) histological and molecular characterization of local and systemic cellular responses, (iii) histological comparison of ex vivo skin models: mouse, pig, cow, human, (iv) effects of ulcerative skin diseases on particle uptake, distribution and cellular and tissue responses in mouse models. Work program consists of (i) characterization of the local penetration and systemic distribution of surface functionalized SiO2 nanoparticles of different shapes and sizes in mouse skin models, (ii) comparison of ex vivo cow and pig skin models with mouse and human skin, (iii) mouse model of epithelial barrier defects: influence on particle distribution and tissue reaction patterns

    Projektleitung: Univ.-Prof. Dr. Achim Dieter Gruber, Dr. Olivia Kershaw
    Eintragende Einrichtung: Institut für Tierpathologie
    Projektlaufzeit: 01.07.2010 bis 30.06.2014
    Projekttyp: Forschungsprojekt
    • Titel: SPP 1313 Biological Responses to Nanoscale Particles (Bio-Nano-Responses)
    • Sprecher: Duisburg-Essen, Universität
    • Partner: MagForce Nanotechnologies AG Berlin, Charité - Universitätsmed.Berlin, Freie Universität Berlin
    Mittelgeber: FG - Sachbeihilfe