Fachbereich Veterinärmedizin



    Anti-tick vaccines to prevent tick-borne diseases in Europe


    Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe. During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against selected tick proteins can lead to decreased pathogen transmission by inhibiting tick feeding – known as ‘tick immunity’ – or by neutralizing tick proteins that facilitate the transmission of tick-borne pathogens. Therefore, anti-tick vaccines encompass an innovative strategy to prevent tick-borne diseases in humans, or animals and wildlife to indirectly reduce the risk of contracting tick-borne diseases for humans.
    Using state of the art proteomic and transcriptomic approaches, this project will identify and characterize novel tick salivary gland proteins involved in ‘tick immunity’ and tick-borne pathogen transmission. These proteins will be subsequently assessed as anti-tick vaccines to protect against Lyme borreliosis, babesiosis and tick-borne encephalitis in animal models. In addition, through an integrated and multidisciplinary approach involving Central and Eastern European public health institutes, health organizations and industrial companies we will examine how to develop anti-tick vaccines and implement these in public health systems

    Projektleitung: Dr. Ard Nijhof
    Eintragende Einrichtung: Institut für Parasitologie und Tropenveterinärmedizin
    Projektlaufzeit: 01.12.2013 bis 30.11.2018
    Projekttyp: Forschungsprojekt
    • Sprecher: Dr. Joppe Hovius, Academic Medical Center University of Amsterdam
    • Partner: Academic Medical Center University of Amsterdam, the Netherlands Biology Centre, Academy of Sciences of the Czech Republic Center for Cooperative Research in Biosciences, Spain GenXPro, Germany National Institute for Public Health and the Environment, the Netherlands Institute of Virology, Slovak Academy of Sciences
    Mittelgeber: EU FP7 program