Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe. During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against selected tick proteins can lead to decreased pathogen transmission by inhibiting tick feeding – known as ‘tick immunity’ – or by neutralizing tick proteins that facilitate the transmission of tick-borne pathogens. Therefore, anti-tick vaccines encompass an innovative strategy to prevent tick-borne diseases in humans, or animals and wildlife to indirectly reduce the risk of contracting tick-borne diseases for humans.
|Projektleitung:||Dr. Ard Nijhof|
|Eintragende Einrichtung:||Institut für Parasitologie und Tropenveterinärmedizin|
|Projektlaufzeit:||01.12.2013 bis 30.11.2018|
|• Sprecher:||Dr. Joppe Hovius, Academic Medical Center University of Amsterdam|
|• Partner:||Academic Medical Center University of Amsterdam, the Netherlands Biology Centre, Academy of Sciences of the Czech Republic Center for Cooperative Research in Biosciences, Spain GenXPro, Germany National Institute for Public Health and the Environment, the Netherlands Institute of Virology, Slovak Academy of Sciences|
|Mittelgeber:||EU FP7 program|