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    Generation of bovine herpesvirus type 1 BAC clones, gE and double mutants/Amendment

    Projektbeschreibung:

    Development of recombinant equine herpesvirus type-1 vectored gG vaccine against Rabies: Rabies virus (RV) is a neurotropic virus that causes a serious impact on animal and human health. It is the type-species of the Lyssavirus genus of the Rhabodviridae family in the Mononegavirales order. RV is an enveloped virus with a single-strand, negative sense RNA genome. The RV genome encodes five proteins: the nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and the viral RNA polymerase (L). Most rabies vaccines currently available in the market use attenuated or inactivated viruses as antigens. To overcome the problems related to the use of current live attenuated (e.g. residual pathogenicity) and inactivated (e.g. costly, frequent boosters required) vaccines, there is a need for novel vaccine strategies)

    Projektleitung: Univ.-Prof. Dr. Nikolaus Osterrieder
    Eintragende Einrichtung: Institut für Virologie
    Projektlaufzeit: 01.11.2011 bis 31.12.2013
    Projekttyp: Forschungsprojekt
    Mittelgeber: Boehringer Ingelheim Vetmedica GmbH