Die porcinen endogenen Retroviren (PERV) sind in das Genom aller Schweine integriert. PERV-A und PERV-B sind in der Lage, menschliche Zellen zu infizieren, während PERV-C nur Schweinezellen infiziert. Darüber hinaus wurden rekombinante Hochtiter-PERV-A/C gefunden, die auch menschliche Zellen infizieren. Da PERV nicht durch frühzeitiges Absetzen, Kolostrumabgabe, antivirale Mittel, Impfstoffe oder Embryotransfer aus den Spenderschweinen eliminiert werden können, stellen sie ein Risiko für die Xenotransplantation dar. Die Impfung ist ein hervorragendes Mittel zur Verhinderung einer Virusinfektion. Obwohl die Impfung gegen das humane Immundefizienzvirus (HIV) immer noch erfolglos ist, hat sich die Impfung gegen einfache Retroviren wie die Gammaretroviren als sehr erfolgreich erwiesen. Impfstoffe gegen das Katzenleukämievirus (FeLV) sind seit Jahrzehnten auf dem Markt. FeLV ist eng mit PERV verwandt. Daher werden wir PERV-Impfstoffe erforschen, entwickeln und sie in vitro und in vivo testen.

Weaning is a stressful period for piglets due to changes in diet composition, Environment and bacterial challenges, contributing to reduced feed intake and depressions in growth rate. To date, not a single strategy has proved to be very effective and it is probable that the most successful Approach on a farm will involve a combination of diet modification and other preventive measures. Therefore, the aim of the study is to test the efficacy of different blends alone or in combination supplemented to basal starter and grower diets fed to post-weaning piglets from d 25 to 66 d of age at recommended dose Levels. Impacts will be demonstrated on growth Performance and Health Status throughout the 42-d experimental period. For comparison, piglets will be fed corresponding basal diets without application of the different blends or with Addition of zinc oxide at the therapeutic dose 3,000 ppm during the starter period.

Test for providing evidence for efficacy of BalanGut supplemented at dosage of 5.0 g/kg feed in to basal gestation and lactation diets of multiparous sows during whole gestation until d 26 post-farrowing (140-d feeding period) haused in a commercial pig-breeding farm. Moreover, litters and post-weaning piglets of sows fed without or with BalanGut will be supplemented with BalanGut at dose levels of 5 g/kg feed (creep feed), 3.0 g/kg feed (starter feed), and 1.5 g/kg feed (grower feed), respectively. Responses will be demonstrated on reproductive performance (body weight, back fat thickness, feed intake, piglet losses until weaning, litter- and individual-based body weight gain of suckling piglets from cross-fostering up to weaning, creep feed intake per litter), and post weaning growth performance (body weight, bod weight gain, feed intake, feed-to-gain-ratio). In addition, health status including scoring of fecal consistency of sows, litters and post-weaning piglets will be determined. For comparison, sows and their piglets will be fed basal diets without containing BalanGut.

The current Experiment will study the effects of the use of Natuphos R at three dose Levels (500, 1.500 and 3.000 FTU) supplemented in a diet containing phytate in comparison with a diet free of phytate, in weaned iglets from 25 until 52 days of age. We will explore the possible mechanisms beyond the effect of the high doses of phytase in the growth of piglets while having mucosa and associated tissues in Focus.

Tannins are commonly considered as anti-nutritional factors in monogastric animals nutrition with attributed negative effects on feed intake, nutrient digestibility and performance. Diarrhea among post-weaning piglets is one of the most important health conditions in pigs farming. Decades of extensive antibiotics use in prevention and therapy of infections in animals significantly contributed to spread of antimicrobial resistance, and in consequence restrictions on their use in farming. The aim of this project is to address the paradigm of the anti-nutritional properties of tannins by verification of the general hypothesis, that specific hydrolysable and condensed tannins contained in LSH and FBP (both plant materials available in large quantities) can improve intestinal homeostasis, beneficially influence intestinal microbiota as well as prevent piglets from ETEC infections, without expressing negative effects on their health status.